Antimicrobial activity

In in vitro testing AQUACEL ® Ag dressing:

  • provides rapid and sustained antimicrobial activity1,2,3.
  • provides sustained antimicrobial activity for up to 7 days2.
  • is effective against Pseudomonas aeruginosa and Staphylococcus aureus over 7 days2.

Antimicrobial-activity

Ionic silver starts killing a broad spectrum of pathogens within 30 minutes of exposure to the dressing as demonstrated by in vitro testing, including MRSA and VRE1


Aerobic and anaerobic isolates included in this study 1:

Antimicrobial efficacy of silver-containing dressings against Pseudomonas aeruginosa over a 7-day period (reinoculation occurred at 48 hours) in in vitro testingg,h,4

Antimicrobial-activity_g1

The silver in the dressing kills wound bacteria held in the dressing5.


In in vitro testing, AQUACEL ® Ag dressing conformed closely to the wound surface6.

conformed-closely

designed to limit spaces where bacteria can thrive


Kills wound bacteria in the dressing

Rapid Confocal Laser Scanning Microscopy5 allows 'real-time' visualisation of bacterial sequestration within gelling AQUACEL ® Ag dressings.

Using two special dyes, it is possible to show whether bacteria are alive (green) or dead (red) in the presence of silver ions.

Rapid-Confocal_240

1. A cross-section of the AQUACEL ® Ag dressing (~20-30 μm) shows bacteria sequestered within

2. As silver ions are made available in the dressing, bacteria are shown to be rapidly killed.

These images illustrate that bacteria are killed within the dressing.

Aerobic bacteria:

  • Staphylococcus aureus (NCTC 8532)
  • Staphylococcus aureus (clinical isolate)
  • Pseudomonas aeruginosa (clinical isolate, x2 strains)
  • Enterobacter cloacae (clinical isolate)
  • Streptococcus pyogenes (clinical isolate)
  • Klebsiella pneumoniae (clinical isolate, x3 strains)
  • Enterococcus faecalis (clinical isolate)
  • Escherichia coli (NCIMB 8545)
  • Escherichia coli (NCIMB 10544)
  • Acinetobacter baumannii (NCIMB 9214)

Anaerobic bacteria:

  • Bacteroides fragilis (clinical isolate)
  • Bacteroides fragilis (NCTC 9343)
  • Peptostreptococcus anaerobius (clinical isolate)
  • Clostridium ramosum (clinical isolate)
  • Clostridium clostridioforme (clinical isolate)
  • Clostridium cadaveris (clinical isolate)
  • Clostridium perfringens (clinical isolate)
  • Tissierella praeacuta (clinical isolate)

Yeasts:

  • Candida albicans (NCPF 3179)
  • Candida albicans (NCPF 3265)
  • Candida krusei (NCPF 3876)

Antibiotic-resistant bacteria:

  • MRSA (NCTC 10442)
  • MRSA (NCTC 12232)
  • MRSA (clinical isolate, x8 strains)
  • VRE (NCTC 12201)
  • VRE (clinical isolate, x2 strains)
  • Serratia marcescens (clinical isolate)
  • Pseudomonas aeruginosa (NCTC 8506)

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